Indianapolis Colts quarterback Peyton Manning's little brother, Eli Manning, was drafted by the San Diego Chargers No. 1 overall in 2004 and promptly traded to the New York Giants. The brothers didn't meet on the gridiron, however, until the Colts traveled to New York to open the 2006 NFL season.
Peyton and his Colts won the game, 26-21, and the elder Manning may have had a slight edge in yardage, as most would have probably expected going in. But little brother held his own, going 20-of-34 for 247 yards, two touchdowns, and one interception in the much-hyped duel.
For the record, Peyton was 25-of-41 for 276 yards, one touchdown, and one interception. Not his greatest game statistically, but enough to get the job done.